Vancomyzer™
AUC-Guided Vancomycin Dosing Calculator
We use the Colin 2019 two-compartment population PK model — a peer-reviewed model published in Clinical Pharmacokinetics and referenced in the 2020 ASHP/IDSA consensus guidelines. Every parameter is published. Every equation is shown. Nothing is hidden.
AUC Calculation Result
Within TargetAUC₂₄
487 mg·h/L
Target
400–600
The Clinical Engine
Built on peer-reviewed science. Every parameter published, every equation verifiable.
Colin 2019 Two-Compartment Model
- CL — Clearance (L/h)
- V1 — Central volume of distribution (L)
- Q — Intercompartmental clearance (L/h)
- V2 — Peripheral volume of distribution (L)
Colin PJ et al. (2019) — Validated 2-compartment population PK model for vancomycin.
Covariates
- Age (years)
- Total body weight (kg)
- Serum creatinine (mg/dL) — direct, not Cockcroft-Gault estimated CrCl
Direct SCr avoids the biases inherent in Cockcroft-Gault estimation, particularly in elderly, obese, and critically ill patients.
Bayesian MAP Estimation
- Nelder-Mead simplex optimization
- Maximum a posteriori (MAP) parameter estimation
- Population priors from Colin 2019 model
- Individual posteriors updated with measured levels
Bayesian estimation integrates population-level PK knowledge with patient-specific drug levels for individualized dosing.
Guideline-Compliant Target
- AUC₂₄ target: 400–600 mg·h/L
- Per 2020 ASHP/IDSA/PIDS consensus guidelines
- Replaces trough-based monitoring
- Rybak MJ et al. (2020) — Consensus guidelines
AUC-guided monitoring has been shown to reduce nephrotoxicity compared to trough-based approaches.
Three Dosing Workflows
Whether you have zero, one, or two measured levels — Vancomyzer™ adapts to your clinical scenario.
Empiric
No Levels
Population prior–based dosing when no drug levels are available. Uses the Colin 2019 model with patient demographics to estimate initial PK parameters and recommend a starting dose.
1 Level
Single Measured
Bayesian posterior estimation with one measured vancomycin concentration. Updates population priors with real patient data for a more individualized dose adjustment.
2 Levels
Full MAP
Full maximum a posteriori (MAP) estimation using two measured concentrations. Provides the most accurate individualized PK parameter estimation for precision dosing.
Patient Safety, Built In
Safety isn't an afterthought. Every guardrail is designed to protect patients and support clinical judgment.
RRT Safety Block
Automatic block for patients on renal replacement therapy. The Colin 2019 model is not validated for dialysis patients — Vancomyzer™ prevents inappropriate use.
Bedbound / Elderly Advisory
Flags patients who are bedbound or elderly where weight-based estimates may be less reliable. Prompts the clinician to consider alternative assessment.
Age >65 Enhanced Monitoring
Triggers enhanced monitoring recommendations for patients over 65, acknowledging the higher nephrotoxicity risk in this population.
Infusion Rate Enforcement
Enforces a maximum infusion rate of 10 mg/min to prevent red man syndrome and infusion-related adverse reactions.
500 mg Minimum Dose Filter
Filters out dose recommendations below 500 mg to ensure clinically practical dosing that aligns with standard vancomycin vial sizes and practice patterns.
Radical Transparency
We don't hide our math behind a black box. Every calculation is verifiable, every reference is linked, every limitation is disclosed.
All PK Equations Shown
Every pharmacokinetic equation used in the calculation is displayed alongside the result. You see the math, not just the answer.
CL, V1, Q, V2 parameter equations with covariate adjustments fully visible.
DOI-Linked References
Every assumption and parameter links directly to the published literature via DOI. Verify any value against the source publication in one click.
Colin PJ et al. (2019), Rybak MJ et al. (2020), Hall NM et al. (2024).
Assumptions & Limitations Displayed
No hidden caveats. Vancomyzer™ explicitly states the assumptions of the model, the populations it was validated in, and where it should not be used.
Model limitations, population scope, and clinical disclaimers are shown with every result.
Multi-Dose Accumulation Visualization
See the full concentration-time profile across multiple doses. Watch drug levels accumulate toward steady state with the AUC target zone clearly highlighted.
- Multiple-dose accumulation curve
- Steady-state shading and indicators
- AUC₂₄ target zone (400–600 mg·h/L) highlighted
- Individual dose markers with infusion timing
- Exportable for clinical documentation
Vancomycin 1250 mg q12h — Steady-State Projection
Cpeak
38.2
mg/L
Ctrough
14.6
mg/L
AUC₂₄
487
mg·h/L
Quick Calc
AUC₂₄
487
mg·h/L
✓ Within Target Range
Vancomyzer™ in Your Pocket
iOS & Android native apps with the same transparent clinical engine. Calculate AUC at the bedside, in the pharmacy, or on rounds.
- Full Bayesian PK engine — same as the web app
- Works offline for secure environments
- Touch-optimized for rapid bedside entry
- Push notifications for level timing reminders
Ready to See the Math?
Start using Vancomyzer™ today — free for individual pharmacists, with institutional plans for hospital departments.