Dōsys Health · clinical decision support for hospital pharmacy
Clinical dosing software you can audit.
Dōsys builds Bayesian dosing calculators for hospital pharmacy. Vancomyzer for vancomycin today; parenteral nutrition in evaluation. Every model, equation and check is published. Independent clinical validation is pending.
Product
Available now, free for individual clinicians.
Vancomyzer™
Bayesian AUC-guided vancomycin dosing for adults on intermittent IV therapy.
- Colin 2019 two-compartment population PK model
- Initial regimens and level-based Bayesian adjustment
- Population-model equations, inputs and sources to review
- Multi-regimen comparison grid
Scope: Adults receiving intermittent IV vancomycin; not for children, dialysis or continuous infusion. Recommendations require review by a licensed clinician.
- 1Recommended regimen with infusion duration, and the model it came from
- 2AUC₂₄, peak and trough with the target range stated next to the number
- 3Concentration–time profile for the selected regimen
- 4Alternative regimens with the same parameters, and the PK parameters themselves
Dōsys Parenteral Nutrition
A workspace for adult PN regimens — energy, protein, dextrose, lipid and fluid in one view, with the calculation and source behind each warning. Evaluation release for synthetic adult cases only; not for patient care until independent validation is complete.
Evidence status
What has been checked, by whom, and what has not.
What you can review before you rely on it
The table distinguishes published model evidence and developer-run checks from independent product validation.
| Item | What it covers | Status |
|---|---|---|
| Population model | Colin 2019 two-compartment model; equations published on vancomyzer.com | Published |
| Literature reproducibility and synthetic checks | Published cases and synthetic patients run through the calculator by the developer | Developer-run |
| Comparison with Tucuxi | Synthetic comparison against a separately built dosing program, scored against pre-set criteria | Developer-run |
| Independent clinical validation | Study with patient data at a participating institution | Pending |
| FDA review | Designed to meet non-device CDS criteria, FD&C §520(o)(1)(E); not reviewed by the FDA | Not reviewed |
Company
Mario Cardenas, PharmD, MBA
Clinical pharmacist · founder and CEO, Dōsys Health LLC
He develops the product, checks its calculations and answers questions about the methods and proposed validation study. Independent evaluation is being arranged; the results of his own work do not establish performance in patient care.
Institutions
Pharmacy departments and health systems.
Access and institutional requirements
Saved history and institutional features remain restricted and are not currently available for new access requests. You may register your interest using the access-request topic.
Evaluation study
Independent validation needs a participating institution. Scope, approvals and data handling are agreed before any work with patient data. A contact request does not enroll a hospital or authorize clinical use.
Data handling
Institutional data use and any business associate agreement are reviewed before setup. The privacy policy states what is stored and where.